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KMID : 0043319970200050510
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Archives of Pharmacal Research
1997 Volume.20 No. 5 p.510 ~ p.512
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Inhibitory Effects of Noscapine on Dopamine Biosynthesis in PC12 cells
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Shin Jung-Soo
Lee Sang-Sun
Lee Myung-Koo
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Abstract
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The effects of noscapine a phthalide isoquinoline alkaloid, on dopamine biosynthesis and tyrosine hydroxylase (TH) activity in PC12 cells were investigated. Noscapine showed 74.6% inhibition on dopamine content in PC12 cells at a concentration of of noscapine was TH activity was inhibited by the treatment of noscapine in PC12 cells (20.9% inhibition at 20 .mu.M). Therefore, the inhibition of TH activity by noscapine might be involved in at least one component of the reduction of dopamine biosynthesis in PC12 cells.
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KEYWORD
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Noscapine, Dopamine Biosynthesis, Tyrosine Hydroxylase, PC12 Cells
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